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Disclosure - Summary of Significant Accounting Policies - Schedule of Cash, Cash Equivalents and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Schedule of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Summary of Significant Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - License, Collaboration, and Funding Agreements - Genzyme Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - License, Collaboration, and Funding Agreements - Georgetown Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - License, Collaboration, and Funding Agreements - Beth Israel Deaconess Medical Center Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - License, Collaboration, and Funding Agreements - Research and Development Incentive Program (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - License, Collaboration, and Funding Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Product Revenue, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Product Revenue, Net - Product Reserve (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Product Revenue, Net - Accounts Receivable Roll Forward (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Fair Value of Financial Assets and Liabilities - Measured on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Fair Value of Financial Assets and Liabilities - Debt Securities Available-for-Sale (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Fair Value of Financial Assets and Liabilities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Fair Value of Financial Assets and Liabilities -Aggregate Fair Value of Warrant and Derivative Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Fair Value of Financial Assets and Liabilities - Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Fair Value of Financial Assets and Liabilities - Goodwill Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Intangible Asset, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - 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Disclosure - Net Loss per Share - Schedule of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Share Attributable to Common Stockholders (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Loss on Transfer of Nonfinancial Assets - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955578 - Disclosure - Segment Reporting (Details) link:presentationLink link:calculationLink link:definitionLink 9955579 - Disclosure - Segment Reporting - Other Segment Disclosures (Details) link:presentationLink link:calculationLink link:definitionLink 9955580 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink